Journal of Cardiovascular Electrophysiology, 15, 1177–1185. Adaptive diastolic interval control of cardiac action potential duration alternans. A quantitative description of membrane current and its application to conduction and excitation in nerve. Experimental control of cardiac muscle alternans. Termination of atrial fibrillation using pulsed low-energy far-field stimulation. Vortex dynamics in three-dimensional continuous myocardium with fiber rotation: filament instability and fibrillation. Multiple mechanisms of spiral wave breakup in a model of cardiac electrical activity. Spatiotemporal control of cardiac alternans. Physical Review Letters, 96, 104101.Įchebarria, B., & Karma, A. Control of electrical alternans in canine cardiac purkinje fibers. Control of electrical alternans in simulations of paced myocardium using extended time-delay autosynchronization. Journal of Electrocardiology, 17, 209–218.īerger, C. Fluctuations in T-wave morphology and susceptibility to ventricular fibrillation. Systems & Control Letters, 7, 11–17.Īdam, D. Local feedback stabilization and bifurcation control, I. This process is experimental and the keywords may be updated as the learning algorithm improves.Ībed, E. These keywords were added by machine and not by the authors. FFP exploits tissue heterogeneity, such as interfaces between regions of healthy cells and dead (electrically non-conducting) ones, as a means of creating “virtual electrodes.” Importantly, studies suggest that FFP can successfully terminate arrhythmias such as fibrillation using far less energy than point stimulation, potentially sparing patients from the excruciating pain associated with traditional ICD intervention. A newer approach, known as far-field pacing (FFP), involves application of a pulsed electric field across the entire heart. The traditional method, point stimulation, involves the delivery of spatially localized electrical shocks through the tip of an electrode, and is the basis for medical devices such as the implantable cardioverter defibrillator (ICD). Here, we shall describe two vastly different methods for controlling cardiac rhythm and how those methods can be modeled mathematically. Patients with certain types of arrhythmias receive surgically-implanted devices which are designed to intervene when severe abnormalities are detected. Precisely coordinated rhythmic contraction of heart muscle tissue is essential for the effective pumping of blood, and abnormal cardiac rhythms (arrhythmias) can be fatal.
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